Séminaire OrléansWhy are lamellipodia flat?
C. Schmeiser (Vienne)
Thursday 12 December 2013 14:30 - Orléans - Amphithéâtre S
A new modelling approach for sections of lamellipodia will be presented, where a stochastic model for the nucleation and polymerization of individual actin filaments is coupled with an obstacle problem describing the deformation of the cell membrane. The main new modeling idea is an interaction between filament dynamics and local membrane geometry. An important player in this context is the protein IRSp53, which combines a function as an anchor between the cell membrane and branching/polymerization agents on the one hand with an influence on (and sensitivity to) the membrane geometry. Without any predetermined geometric restrictions, simulations of the coupled model predict flat lamellipodia. (joint work with Christoph Winkler)